Product Name               :    Thiocolchicoside

CAS No.                           :     602-41-5

Chemical Formula        :     C27H33NO10S

Molecular Weight         :     563.62 g/mole

Chemical name                N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)

                                                oxan-2-yl]oxy-6,7-dihydro-5H-enzo[d]heptalen-7-yl] acetamide 

 

Physical and Chemical Properties


Physical state and appearance  : Yellow crystalline solid powder.

Purity       :     ≥ 99.0 %

Solubility :     Soluble in Water & Alcohol

 

Thiocolchicoside is a semi-synthetic derivative of the naturally occurring compound colchicoside extracted from the seeds of Gloriosa superba.

 

Thiocolchicoside is a muscle relaxant agent with anti-inflammatory and analgesic actions, also is used topically for the treatment of muscular spasms and for rheumatologic, orthopedic, and traumatologic disorders.

 

Pharmacology


Thiocolchicoside binds to GABA-A and strychnine sensitive glycine receptors. Thiocolchicoside acting as a GABA-A receptor antagonist, its myorelaxant effects could be exerted at the supra-spinal level, via complex regulatory mechanisms, although a glycinergic mechanism of action cannot be excluded. The characteristics of the interaction of Thiocolchicoside with GABA-A receptors are qualitatively and quantitatively shared by its main circulating metabolite, the glucuronidated Derivative. Thiocolchicoside is rapidly absorbed after oral administration, and metabolized into 3 main metabolites. The two main circulating forms were the Thiocolchicoside aglycon and the glucuronidated derivative of Thiocolchicoside, which is active. Thiocolchicoside is well tolerated oral administration for periods of up to 6 months.

 

Dosage & Administration


Thiocolchicoside is given by the oral & intramuscular route. Adult for Muscle Spasms : Initially 16 mg Daily , Oral and up to 8mg daily intramuscular.